Well-string configuration for dissolution acceleration in CO₂ storage is completely modeled and simulated. The code validation is also performed. It is concluded that required top well compression pressure to inject CO₂ will decrease by simultaneous injecting CO₂ and Brine; increase in “salinity” and “surface temperature” decrease dissolved CO₂; CO₂injecting with higher bottom well pressure raises CO₂ dissolution; single-phase homogeneous CO₂-Brine fluid flow assumption leads to considerable error in the tubing pressure profile; and concentration profile has not significant effect on tubing pressure profile.